Publications

2018

Brief Report: Clusters and Trajectories Across the Autism and/or ADHD Spectrum.
LaBianca, S., Pagsberg, A. K., Jakobsen, K. D., Demur, A. B., Bartalan, M., LaBianca, J., & Werge, T. (2018).
Journal of Autism and Developmental Disorders. DOI: 10.1007/s10803-018-3618-6

Elevated polygenic burden for autism is associated with differential DNA methylation at birth.
Hannon, E., Schendel, D., Ladd-Acosta, C., Grove, J., Hansen, C. S., Andrews, S. V., … iPSYCH-Broad ASD Group (2018).
Genome Medicine, 10(1), 19. DOI: 10.1186/s13073-018-0527-4

Attitudes of stakeholders in psychiatry towards the inclusion of children in genomic research.
Sundby, A., Boolsen, M. W., Burgdorf, K. S., Ullum, H., Hansen, T. F., & Mors, O. (2018).
Human Genomics, 12(1), 12. DOI: 10.1186/s40246-018-0144-8

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection.
Pardiñas, A. F., Holmans, P., Pocklington, A. J., Escott-Price, V., Ripke, S., Carrera, N., … GERAD1 Consortium: (2018).
Nature Genetics. DOI: 10.1038/s41588-018-0059-2

Novel approach for CES1 genotyping: integrating single nucleotide variants and structural variation.
Bjerre, D., & Berg Rasmussen, H. (2018).
Pharmacogenomics. DOI: 10.2217/pgs-2016-0145

Carboxylesterase 1 genes: systematic review and evaluation of existing genotyping procedures.
Rasmussen, H. B., Madsen, M. B., INDICES Consortium, Plessen , K. J., Jeppesen, P., Houmann, T., … Pagsberg, A. K. (2018).
Drug Metabolism and Personalized Therapy. DOI: 10.1515/dmpt-2017-0023

Heritability of Schizophrenia and Schizophrenia Spectrum Based on the Nationwide Danish Twin Register.
Hilker, R., Helenius, D., Fagerlund, B., Skytthe, A., Christensen, K., Werge, T. M., … Glenthøj, B. (2018).
Biological Psychiatry, 492-498. [83]. DOI: 10.1016/j.biopsych.2017.08.017

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap.
Gandal, M. J., Haney, J. R., Parikshak, N. N., Leppa, V., Ramaswami, G., Hartl, C., … CommonMind Consortium (2018).
Science, 359(6376), 693-697. DOI: 10.1126/science.aad6469

Altered auditory processing and effective connectivity in 22q11.2 deletion syndrome.
Larsen, K. M., Mørup, M., Birknow, M. R., Fischer, E., Hulme, O., Vangkilde, A., … Garrido, M. I. (2018).
Schizophrenia research. DOI: 10.1016/j.schres.2018.01.026

22q11.2 Deletion Syndrome Is Associated With Impaired Auditory Steady-State Gamma Response.
Larsen, K. M., Pellegrino , G., Birknow, M. R., Kjær , T. N., Baaré, W. F. C., Didriksen, M., … Siebner, H. R. (2018).
Schizophrenia Bulletin, 44(2), 388-397. DOI: 10.1093/schbul/sbx058

UGT polymorphisms and lamotrigine clearance during pregnancy.
Petrenaite, V., Öhman, I., Ekström, L., Sæbye, D., Hansen, T. F., Tomson, T., & Sabers, A. (2018).
Epilepsy research. DOI: 10.1016/j.eplepsyres.2018.01.011

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
Flannick, J., Fuchsberger, C., Mahajan, A., Teslovich, T. M., Agarwala, V., Gaulton, K. J., … McCarthy, M. I. (2018).
Scientific Data, 5, 180002. DOI: 10.1038/sdata.2018.2

A Genetic Investigation of Sex Bias in the Prevalence of Attention-Deficit/Hyperactivity Disorder.
Martin, J., Walters, R. K., Demontis, D., Mattheisen, M., Lee, S. H., Robinson, E., … 23andMe Research Team (2018).
Biological Psychiatry. DOI: 10.1016/j.biopsych.2017.11.026

Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium.
Peyrot, W. J., Van der Auwera, S., Milaneschi, Y., Dolan, C. V., Madden, P. A. F., Sullivan, P. F., … Hansen, T. F. (2018).
Biological Psychiatry. DOI: 10.1016/j.biopsych.2017.09.009

The iPSYCH2012 case-cohort sample: new directions for unravelling genetic and environmental architectures of severe mental disorders.
Pedersen, C. B., Bybjerg-Grauholm, J., Pedersen, M. G., Grove, J., Agerbo, E., Bækvad-Hansen, M., … Mortensen, P. B. (2018).
Molecular Psychiatry. DOI: 10.1038/mp.2017.196

 

2017

Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations.
Milaneschi, Y., Lamers, F., Peyrot, W. J., Baune, B. T., Breen, G., Dehghan, A., … Werge, T. M. (2017).
Archives of General Psychiatry, 74(12), 1214-1225. DOI: 10.1001/jamapsychiatry.2017.3016

A mouse model of the schizophrenia-associated 1q21.1 microdeletion syndrome exhibits altered mesolimbic dopamine transmission.
Nielsen, J., Fejgin, K., Sotty, F., Nielsen, V., Mørk, A., Christoffersen, C. T., … Didriksen, M. (2017).
Translational psychiatry, 7(11), 1261. DOI: 10.1038/s41398-017-0011-8

Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes.
CORtisolNETwork (CORNET) Consortium, Psychiatric Genomics Consortium (PGC), & Werge, T. M. (2017).
Scientific Reports, 7(1), 15351. DOI: 10.1038/s41598-017-11852-3

Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity.
Joshi, P. K., Pirastu, N., Kentistou, K. A., Fischer, K., Hofer, E., Schraut, K. E., … Wilson, J. F. (2017).
Nature Communications, 8(1), 910. DOI: 10.1038/s41467-017-00934-5

Severe Parkinsonism and Creatine Kinase Increase After Low-Dose Aripiprazole Treatment in a Patient of African Descent.
Jørgensen, A., Thorleifsson, A., Jimenez-Solem, E., Werge, T., & Rasmussen, H. B. (2017).
Journal of Clinical Psychopharmacology, 37(5), 630-631. DOI: 10.1097/JCP.0000000000000750

Stakeholders in psychiatry and their attitudes toward receiving pertinent and incident findings in genomic research.
Sundby, A., Boolsen, M. W., Burgdorf, K. S., Ullum, H., Hansen, T. F., Middleton, A., & Mors, O. (2017).
American Journal of Medical Genetics, Part A, 173(10), 2649-2658. DOI: 10.1002/ajmg.a.38380

CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits.
Macé, A., Tuke, M. A., Deelen, P., Kristiansson, K., Mattsson, H., Nõukas, M., … Kutalik, Z. (2017).
Nature Communications, 8(1), 744. DOI: 10.1038/s41467-017-00556-x

Genetic risk scores and family history as predictors of schizophrenia in Nordic registers.
Lu, Y., Pouget, J. G., Andreassen, O. A., Djurovic, S., Esko, T., Hultman, C. M., … Sullivan, P. F. (2017).
Psychological medicine, 1-9. DOI: 10.1017/S0033291717002665

Analysis of potential protein-modifying variants in 9000 endometriosis patients and 150000 controls of European ancestry.
Sapkota, Y., Vivo, I. D., Steinthorsdottir, V., Fassbender, A., Bowdler, L., Buring, J. E., … Werge, T. M. (2017).
Scientific Reports, 7(1), 11380. DOI: 10.1038/s41598-017-10440-9

Erratum to: A manual-based vocational rehabilitation program for patients with an acquired brain injury: study protocol of a pragmatic randomized controlled trial (RCT)
Hoeffding, L. K., Nielsen, M. H., Rasmussen, M. A., Norup, A., Arango-Lasprilla, J. C., Kjær, U. K., … Schow, T.
DOI: 10.1186/s13063-017-2146-6

Carboxylesterase 1A2 encoding gene with increased transcription and potential rapid drug metabolism in Asian populations.
Rasmussen, H. B., Madsen, M. B., Lyauk, Y. K., Hansen, P. R., Hughes, T. P., INDICES Consortium, … Kaalund-Brok, K. (2017).
Drug Metabolism and Personalized Therapy, 32(3), 163-168. DOI: 10.1515/dmpt-2017-0012

Differential DNA methylation at birth associated with mental disorder in individuals with 22q11.2 deletion syndrome.
Starnawska, A., Hansen, C. S., Sparsø, T., Mazin, W., Olsen, L., Bertalan, M., … Weinsheimer, S. (2017).
Translational psychiatry, 7(8), e1221. DOI: 10.1038/tp.2017.181

A manual-based vocational rehabilitation program for patients with an acquired brain injury: study protocol of a pragmatic randomized controlled trial (RCT).
Hoeffding, L. K., Nielsen, M. H., Rasmussen, M. A., Norup, A., Arango-Lasprilla, J. C., Kjær, U. K., … Quas, K. J. (2017).
Trials, 18(1), 371. DOI: 10.1186/s13063-017-2115-0

Prevalence of restless legs syndrome and associated factors in an otherwise healthy population: results from the Danish Blood Donor Study.
Didriksen, M., Rigas, A. S., Allen, R. P., Burchell, B. J., Di Angelantonio, E., Nielsen, M. H., … Ullum, H. (2017).
Sleep Medicine, 36, 55-61. DOI: 10.1016/j.sleep.2017.04.014

Quetiapine extended release versus aripiprazole in children and adolescents with first-episode psychosis: the multicentre, double-blind, randomised tolerability and efficacy of antipsychotics (TEA) trial.
Pagsberg, A. K., Jeppesen, P., Klauber, D. G., Jensen, K. G., Rudå, D., Stentebjerg-Olesen, M., … Fink-Jensen, A. (2017).
The Lancet Psychiatry, 4(8), 605-618. DOI: 10.1016/S2215-0366(17)30166-9

Reappraisal of the genetic diversity and pharmacogenetic assessment of CES1.
Ferrero-Miliani, L., Bjerre, D., Stage, C., Madsen, M. B., Jűrgens, G., Dalhoff, K. P., & Rasmussen, H. B. (2017).
Pharmacogenomics, 18(13), 1241-1257. DOI: 10.2217/pgs-2017-0052

Lessons to be Learned From 22q2.11 Syndromes-Reply.
Hoeffding, L. K., Pedersen, C. B., & Werge, T. (2017).
Archives of General Psychiatry, 74(7), 757-758. DOI: 10.1001/jamapsychiatry.2017.0837

Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders.
Weiner, D. J., Wigdor, E. M., Ripke, S., Walters, R. K., Kosmicki, J. A., Grove, J., … Hansen, T. F. (2017).
Nature Genetics, 49(7), 978-985. DOI: 10.1038/ng.3863

The impact of CES1 genotypes on the pharmacokinetics of methylphenidate in healthy Danish subjects.
Stage, C., Jürgens, G., Guski, L. S., Thomsen, R., Bjerre, D., Ferrero-Miliani, L., … INDICES Consortium (2017).
British journal of clinical pharmacology, 83(7), 1506-1514. DOI: 10.1111/bcp.13237

The Pharmacokinetics of Enalapril in Relation to CES1 Genotype in Healthy Danish Volunteers.
Stage, C., Jürgens, G., Guski, L. S., Thomsen, R., Bjerre, D., Ferrero-Miliani, L., … INDICES consortium (2017).
Basic & clinical pharmacology & toxicology. DOI: 10.1111/bcpt.12835

22q11 deletion syndrome: Estimate of Schizophrenia Risk and correlations between schizophrenia-like positive and negative symptoms and social impairments.
Vangkilde, A., & Werge, T. M. (2017). 

Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism.
Sapkota, Y., Steinthorsdottir, V., Morris, A. P., Fassbender, A., Rahmioglu, N., De Vivo, I., … Werge, T. M. (2017).
Nature Communications, 8, 15539. DOI: 10.1038/ncomms15539

The catechol-O-methyltransferase (COMT) Val158Met genotype modulates working memory-related dorsolateral prefrontal response and performance in bipolar disorder.
Miskowiak, K. W., Kjaerstad, H. L., Støttrup, M. M., Svendsen, A. M., Demant, K. M., Hoeffding, L. K., … Macoveanu, J. (2017).
Bipolar Disorders (English Edition, Print), 19(3), 214-224. DOI: 10.1111/bdi.12497

Gamma oscillations and effective connectivity in a group at risk of psychosis.
Larsen, K. M., Mørup, M., Siebner, H. R., Baaré, W. F. C., & Werge, T. M. (2017).
Institute for Applied Mathematics and Computer Science, Technical University of Denmark.

Is an Early Age at Illness Onset in Schizophrenia Associated With Increased Genetic Susceptibility? Analysis of Data From the Nationwide Danish Twin Register.
Hilker, R., Helenius, D., Fagerlund, B., Skytthe, A., Christensen, K., Werge, T. M., … Glenthøj, B. (2017).
EBioMedicine, 18, 320-326. DOI: 10.1016/j.ebiom.2017.04.002

Novel procedure with improved resolution and specificity for amplification and differentiation of variants of the gene encoding carboxylesterase 1.
Bjerre, D., Rasmussen, H. B., & INDICES Consortium (2017).
Pharmacogenetics and Genomics, 27(4), 155-158. DOI: 10.1097/FPC.0000000000000267

Association of Carboxylesterase 1 Gene (CES1) Polymorphism with Weight loss in Children with Attention Deficit Hyperactivity Disorder during Methylphenidate Treatment.
Oxenbøll, M., Kaalund-Brok, K., Rasmussen, S., Bjerre, D., Jürgens, G., Hansen, E. H., … The INDICES Consortium (2017).
SM Journal of Bioinformatics and Proteomics, 2(1), 1-8. [1010].

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia.
McLaughlin, R. L., Schijven, D., van Rheenen, W., van Eijk, K. R., O’Brien, M., Kahn, R. S., … Rasmussen, H. B. (2017).
Nature Communications, 8, 14774. DOI: 10.1038/ncomms14774

Nomenclature for alleles of the human carboxylesterase 1 gene.
Rasmussen, H. B., Madsen, M. B., Hansen, P. R., & INDICES Consortium (2017).
Pharmacogenetics and Genomics, 27(2), 78-80. DOI: 10.1097/FPC.0000000000000255

The impact of lifestyle risk factors on the rate of infection after surgery for a fracture of the ankle.
Olsen, L. L., Møller, A. M., Brorson, S., Hasselager, R. B., & Sort, R. (2017).
The bone & joint journal, 99-B(2), 225-230. DOI: 10.1302/0301-620X.99B2.BJJ-2016-0344.R1

Risk of Psychiatric Disorders Among Individuals With the 22q11.2 Deletion or Duplication: A Danish Nationwide, Register-Based Study.
Hoeffding, L. K., Trabjerg, B. B., Olsen, L., Mazin, W., Sparsø, T., Vangkilde, A., … Werge, T. (2017).
Archives of General Psychiatry. DOI: 10.1001/jamapsychiatry.2016.3939

ASD and schizophrenia show distinct developmental profiles in common genetic overlap with population-based social communication difficulties.
St Pourcain, B., Robinson, E. B., Anttila, V., Sullivan, B. B., Maller, J., Golding, J., … iPSYCH-SSI-Broad Autism Group (2017).
Molecular Psychiatry. DOI: 10.1038/mp.2016.198

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects.
CNV and Schizophrenia Working Groups of the Psychiatric Genomics Consortium, Hansen, T. F., Werge, T. M., Olsen, L., & Bertalan, M. (2017).
Nature Genetics, 49(1), 27-35. DOI: 10.1038/ng.3725

Evaluation of shared genetic susceptibility loci between autoimmune diseases and schizophrenia based on genome-wide association studies.
Hoeffding, L. K., Rosengren, A., Thygesen, J. H., Schmock, H., Werge, T., & Hansen, T. (2017).
Nordic Journal of Psychiatry, 71(1), 20-25. DOI: 10.1080/08039488.2016.1198420

Identification of Gene Loci That Overlap Between Schizophrenia and Educational Attainment.
Le Hellard, S., Wang, Y., Witoelar, A., Zuber, V., Bettella, F., Hugdahl, K., … Schizophrenia Working Group of the Psychiatric Genomics Consortium (2017).
Schizophrenia Bulletin, 43(3), 654-664. DOI: 10.1093/schbul/sbw085

Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.
Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium, & Werge, T. M. (2017).
Autism, 8, 21. DOI: 10.1186/s13229-017-0137-9

 

2016

Population Pharmacokinetics of Methylphenidate in Healthy Adults Emphasizing Novel and Known Effects of Several Carboxylesterase 1 (CES1) Variants.
Lyauk, Y. K., Stage, C., Bergmann, T. K., Ferrero-Milliani, L., Bjerre, D., Thomsen, R., … Jürgens, G. (2016).
Clinical and Translational Science, 9(6), 337-345. DOI: 10.1111/cts.12423

Kromosomforandringer, der involverer dopamintransportøren, som årsag til psykiske lidelser.
Høffding, L. K. E., Duong, L., & Rasmussen, H. B. (2016).
BestPractice.

Developing consistency in reaction time associated with stable individual differences in motor system microstructure: A longitudinal DTI study of children and adolescents.
Madsen, K. S., Jernigan, T. L., Reuter, C., Thompson, W. K., & Baaré, W. F. C. (2016).
Abstract fra 46th Society for Neuroscience Meeting, San Diego, USA.

Associations between social cognition, skills, and function and subclinical negative and positive symptoms in 22q11.2 deletion syndrome.
Vangkilde, A., Jepsen, J. R. M., Schmock, H., Olesen, C., Arnarsdóttir, S., Baaré, W. F. C., … Olsen, L. (2016).
Journal of Neurodevelopmental Disorders, 8(1), [42]. DOI: 10.1186/s11689-016-9175-4

Høj risiko for skizofreni-spektrum sygdomme i 22q11.2 deletionssyndrom.
Olsen, L. (2016).
Best Practice – Psykiatri/Neurologi, (35), 32-33.

The influence of genetic constitution on migraine drug responses.
Christensen, A. F., Esserlind, A-L., Werge, T., Stefánsson, H., Stefánsson, K., & Olesen, J. (2016).
Cephalalgia : an international journal of headache, 36(7), 624-39. DOI: 10.1177/0333102415610874

Systems genetics analysis of pharmacogenomics variation during antidepressant treatment.
Madsen, M. B., Kogelman, L. J. A., Kadarmideen, H. N., & Rasmussen, H. B. (2016).
The pharmacogenomics journal. DOI: 10.1038/tpj.2016.68

An epigenetic clock for gestational age at birth based on blood methylation data.
Knight, A. K., Craig, J. M., Theda, C., Bækvad-Hansen, M., Bybjerg-Grauholm, J., Hansen, C. S., … Smith, A. K. (2016).
Genome Biology (Online Edition), 17(1), 206. DOI: 10.1186/s13059-016-1068-z

Digital questionnaire platform in the Danish Blood Donor Study.
Burgdorf, K. S., Felsted, N., Mikkelsen, S., Nielsen, M. H., Thørner, L. W., Pedersen, O. B., … Ullum, H. (2016).
Computer Methods and Programs in Biomedicine, 135, 101-4. DOI: 10.1016/j.cmpb.2016.07.023

No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study.
Johnson, E. C., Bjelland, D. W., Howrigan, D. P., Abdellaoui, A., Breen, G., Borglum, A., … Schizophrenia Working Group of the Psychiatric Genomics Consortium (2016).
P L o S Genetics (Online), 12(10), e1006343. DOI: 10.1371/journal.pgen.1006343

Corrigendum: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.
Gormley, P., Anttila, V., Winsvold, B. S., Palta, P., Esko, T., Pers, T. H., … International Headache Genetics Consortium (2016).
Nature Genetics, 48(10), 1296. DOI: 10.1038/ng1016-1296c

Genetic risk for schizophrenia is associated with an impaired auditory steady-state gamma response.
Larsen, K. M., Pellegrino, G., Rosgaard Birknow, M., Baaré, W. F. C., Didriksen, M., Olsen, L., … Mørup, M. (2016).
Abstract fra The Brain Conferences, Copenhagen, Danmark.

Pharmacodynamic Impact of Carboxylesterase 1 Gene Variants in Patients with Congestive Heart Failure Treated with Angiotensin-Converting Enzyme Inhibitors.
Nelveg-Kristensen, K. E., Bie, P., Ferrero, L., Bjerre, D., Bruun, N. E., Egfjord, M., … Pagsberg, A. K. (2016).
P L o S One, 11(9), e0163341. DOI: 10.1371/journal.pone.0163341

Association of AADAC Deletion and Gilles de la Tourette Syndrome in a Large European Cohort.
Bertelsen, B., Stefánsson, H., Riff Jensen, L., Melchior, L., Debes, N. M. M., Groth, C., … Tümer, Z. (2016).
Biological Psychiatry, 79(5), 383-91. DOI: 10.1016/j.biopsych.2015.08.027

Genome-Wide Association Studies Suggest Limited Immune Gene Enrichment in Schizophrenia Compared to 5 Autoimmune Diseases.
Pouget, J. G., Gonçalves, V. F., Spain, S. L., Finucane, H. K., Raychaudhuri, S., Kennedy, J. L., … Schizophrenia Working Group of the Psychiatric Genomics Consortium (2016).
Schizophrenia Bulletin, 42(5), 1176-84. DOI: 10.1093/schbul/sbw059

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.
Gormley, P., Anttila, V., Winsvold, B. S., Palta, P., Esko, T., Pers, T. H., … International Headache Genetics Consortium (2016).
Nature Genetics, 48(8), 856-66. DOI: 10.1038/ng.3598

Persistent gating deficit and increased sensitivity to NMDA receptor antagonism after puberty in a new mouse model of the human 22q11.2 microdeletion syndrome: a study in male mice.
Didriksen, M., Fejgin, K., Nilsson, S. R. O., Birknow, M. R., Grayton, H. M., Larsen, P. H., … Nielsen, J. (2016).
Journal of psychiatry & neuroscience : JPN, 41(5), 150381.

High loading of polygenic risk in cases with chronic schizophrenia.
Meier, S. M., Agerbo, E., Maier, R., Pedersen, C. B., Lang, M., Grove, J., … MooDS SCZ Consortium (2016).
Molecular Psychiatry, 21(7), 969-74. DOI: 10.1038/mp.2015.130

The association between candidate migraine susceptibility loci and severe migraine phenotype in a clinical sample.
Esserlind, A-L., Christensen, A. F., Steinberg, S., Grarup, N., Pedersen, O., Hansen, T., … Olesen, J. (2016).
Cephalalgia : an international journal of headache, 36(7), 615-23. DOI: 10.1177/0333102415570492

Investigating the impact of missense mutations in hCES1 by in silico structure-based approaches.
Nzabonimpa, G. S., Rasmussen, H. B., Brunak, S., Taboureau, O., INDICES Consortium, Plessen , K. J., … Pagsberg, A. K. (2016).
Drug Metabolism and Personalized Therapy, 31(2), 97-106. DOI: 10.1515/dmpt-2015-0034

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
Winkler, T. W., Justice, A. E., Graff, M., Barata, L., Feitosa, M. F., Chu, S., … arcOGEN Consortium Correction:
DOI: 10.1371/journal.pgen.1006166

Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study.
Prins, B. P., Abbasi, A., Wong, A., Vaez, A., Nolte, I., Franceschini, N., … PAGE Consortium (2016).
PLoS medicine, 13(6), e1001976. DOI: 10.1371/journal.pmed.1001976

The CHANGE trial: no superiority of lifestyle coaching plus care coordination plus treatment as usual compared to treatment as usual alone in reducing risk of cardiovascular disease in adults with schizophrenia spectrum disorders and abdominal obesity.
Speyer, H., Christian Brix Nørgaard, H., Birk, M., Karlsen, M., Storch Jakobsen, A., Pedersen, K. S., … Nordentoft, M. (2016).
World Psychiatry, 15(2), 155-65. DOI: 10.1002/wps.20318

Evidence for Genetic Overlap Between Schizophrenia and Age at First Birth in Women.
Mehta, D., Tropf, F. C., Gratten, J., Bakshi, A., Zhu, Z., Bacanu, S-A., … Schizophrenia Working Group of the Psychiatric Genomics Consortium, LifeLines Cohort Study, and TwinsUK (2016).
Archives of General Psychiatry, 73(5), 497-505. DOI: 10.1001/jamapsychiatry.2016.0129

Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population.
Robinson, E. B., St Pourcain, B., Anttila, V., Kosmicki, J. A., Bulik-Sullivan, B., Grove, J., … Nordentoft, M. (2016).
Nature Genetics, 48(5), 552-5. DOI: 10.1038/ng.3529

Parental Origin of Interstitial Duplications at 15q11.2-q13.3 in Schizophrenia and Neurodevelopmental Disorders.
Isles, A. R., Ingason, A., Lowther, C., Walters, J., Gawlick, M., Stöber, G., … Kirov, G. (2016).
P L o S Genetics, 12(5), e1005993. DOI: 10.1371/journal.pgen.1005993

Schizophrenia Spectrum Disorders in a Danish 22q11.2 Deletion Syndrome Cohort Compared to the Total Danish Population-A Nationwide Register Study.
Vangkilde, A., Olsen, L., Hoeffding, L. K., Pedersen, C. B., Mortensen, P. B., Werge, T., & Trabjerg, B. (2016).
Schizophrenia Bulletin, 42(3), 824-831. DOI: 10.1093/schbul/sbv195

The pleiotropic manifestations of genomic variants – focusing on comment and rare variants in schizophrenia.
Høffding, L. K. E. (2016).

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept.
Franke, B., Stein, J. L., Ripke, S., Anttila, V., Hibar, D. P., van Hulzen, K. J. E., … Schizophrenia Working Group of the Psychiatric Genomics Consortium (2016).
Nature Neuroscience, 19(3), 420-31. DOI: 10.1038/nn.4228

Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics.
Holland, D., Wang, Y., Thompson, W. K., Schork, A., Chen, C-H., Lo, M-T., … Schizophrenia Working Group of the Psychiatric Genomics Consortium (2016).
Frontiers in genetics, 7, 15. DOI: 10.3389/fgene.2016.00015

Schizophrenia risk from complex variation of complement component 4.
Sekar, A., Bialas, A. R., de Rivera, H., Davis, A., Hammond, T. R., Kamitaki, N., … Schizophrenia Working Group of the Psychiatric Genomics Consortium (2016).
Nature, 530(7589), 177-183. DOI: 10.1038/nature16549

Prognostic impact of carboxylesterase 1 gene variants in patients with congestive heart failure treated with angiotensin-converting enzyme inhibitors.
Nelveg-Kristensen, K. E., Madsen, M. B., Torp-Pedersen, C., Køber, L., Egfjord, M., Hansen, T., … Hansen, P. R. (2016).
Pharmacogenetics and Genomics, 26(4), 169-177. DOI: 10.1097/FPC.0000000000000203

Comprehensive analysis of schizophrenia-associated loci highlights ion channel pathways and biologically plausible candidate causal genes.
Pers, T. H., Timshel, P., Ripke, S., Lent, S., Sullivan, P. F., O’Donovan, M. C., … Olsen, L. (2016).
Human molecular genetics, 25(6), 1247-1254. DOI: 10.1093/hmg/ddw007

Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS.
Wang, Y., Thompson, W. K., Schork, A. J., Holland, D., Chen, C-H., Bettella, F., … Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium (2016).
P L o S Genetics (Online), 12(1), e1005803. DOI: 10.1371/journal.pgen.1005803

15q13.3 homozygous knockout mouse model display epilepsy-, autism- and schizophrenia-related phenotypes.
Forsingdal, A., Fejgin, K., Nielsen, V., Werge, T., & Nielsen, J. (2016).
Translational psychiatry, 6(7), e860. DOI: 10.1038/tp.2016.125

Electrophysiological characterisation of 22q11.2 deletion carriers – A translational investigation in humans and mice.
Rosgaard Birknow, M. (2016).

High-Quality Exome Sequencing of Whole-Genome Amplified Neonatal Dried Blood Spot DNA.
Poulsen, J. B., Lescai, F., Grove, J., Bækvad-Hansen, M., Christiansen, M., Hagen, C. M., … Hollegaard, M. V. (2016).
P L o S One, 11(4), e0153253. DOI: 10.1371/journal.pone.0153253

Investigation of SNP rs2060546 Immediately Upstream to NTN4 in a Danish Gilles de la Tourette Syndrome Cohort.
Padmanabhuni, S. S., Houssari, R., Esserlind, A-L., Olesen, J., Werge, T. M., Hansen, T. F., … Tümer, Z. (2016).
Frontiers in Neuroscience, 10, 531. DOI: 10.3389/fnins.2016.00531

Risk of Mental Disorders in 22q11.2 Deletion and Duplication Syndrome: A Nation-wide Study..
Høffding, L. K. E., Olsen, L., Mazin, W., Vangkilde, A., & Werge, T. M. (2016).
Abstract fra 10th Biennial International 22q11.2 Confenrence, Sirmione, Italien.

RNA Sequencing of Trigeminal Ganglia in Rattus Norvegicus after Glyceryl Trinitrate Infusion with Relevance to Migraine.
Hougaard Pedersen, S., Maretty, L., Ramachandran, R., Sibbesen, J. A., Yakimov, V., Elgaard-Christensen, R., … Jansen-Olesen, I. (2016).
P L o S One, 11(5), e0155039. DOI: 10.1371/journal.pone.0155039

Switch in Therapy from Methylphenidate to Atomoxetine in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: An Analysis of Patient Records.
Warrer, P., Thomsen, P. H., Dalsgaard, S., Hansen, E. H., Aagaard, L., Wallach Kildemoes, H., & Rasmussen, H. B. (2016).
Journal of Child and Adolescent Psychopharmacology, 26(4), 354-361. DOI: 10.1089/cap.2015.0060

The effect of COMT val158met genotype on neural response and performance during spatial working memory in remitted patients with bipolar disorder.
Høffding, L. K. E. (2016).

Transcriptional interactions suggest niche segregation among microorganisms in the human gut.Plichta, D. R., Juncker, A. S., Bertalan, M., Rettedal, E., Gautier, L., Varela, E., … Metagenomics of the Human Intestinal Tract (MetaHIT) Consortium (2016).
Future Microbiology, 1, 16152. DOI: 10.1038/nmicrobiol.2016.152

 

2015

Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness.
Bigdeli, T. B., Ripke, S., Bacanu, S-A., Lee, S. H., Wray, N. R., Gejman, P. V., … Schizophrenia Working Group of the Psychiatric Genomics Consortium (2015).
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. DOI: 10.1002/ajmg.b.32402

An Empirical Bayes Mixture Model for Effect Size Distributions in Genome-Wide Association Studies.
Thompson, W. K., Wang, Y., Schork, A. J., Witoelar, A., Zuber, V., Xu, S., … Schizophrenia Working Group of the Psychiatric Genomics Consortium (2015).
P L o S Genetics (Online), 11(12), e1005717. DOI: 10.1371/journal.pgen.1005717

Association Study of CHRNA7 Promoter Variants with Sensory and Sensorimotor Gating in Schizophrenia Patients and Healthy Controls: A Danish Case-Control Study.
Bertelsen, B., Oranje, B., Melchior, L., Fagerlund, B., Werge, T. M., Mikkelsen, J. D., … Glenthøj, B. Y. (2015).
NeuroMolecular Medicine, 17, 423-30. DOI: 10.1007/s12017-015-8371-9

Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis.
Loh, P-R., Bhatia, G., Gusev, A., Finucane, H. K., Bulik-Sullivan, B. K., Pollack, S. J., … Schizophrenia Working Group of the Psychiatric Genomics Consortium (2015).
Nature Genetics, 47(12), 1385-92. DOI: 10.1038/ng.3431

Linkage and whole genome sequencing identify a locus on 6q25-26 for formal thought disorder and implicate MEF2A regulation.
Thygesen, J. H., Zambach, S. K., Ingason, A., Lundin, P., Hansen, T. F., Berlatan, M., … Werge, T. (2015).
Schizophrenia research, 169(1-3), 441–446. DOI: 10.1016/j.schres.2015.08.037

Identification of rare high-risk copy number variants affecting the dopamine transporter gene in mental disorders.
Hoeffding, L. K., Duong, L. T. T., Ingason, A., Rosengren, A., Sorbanski, E., Witt, S. H., … Rasmussen, H. B. (2015).
Nordic Journal of Psychiatry, 1-4. DOI: 10.3109/08039488.2015.1095944

Two rare deletions upstream of the NRXN1 gene (2p16.3) affecting the non-coding mRNA AK127244 segregate with diverse psychopathological phenotypes in a family.
Duong, L. T., Hoeffding, L. K., Petersen, K., Knudsen, H. C., Thygesen, J. H., Klitten, L. L., … Werge, T. (2015).
European Journal of Medical Genetics. DOI: 10.1016/j.ejmg.2015.11.004

An atlas of genetic correlations across human diseases and traits.
Bulik-Sullivan, B., Finucane, H. K., Anttila, V., Gusev, A., Day, F. R., Loh, P-R., … ReproGen Consortium (2015).
Nature Genetics, 47(11), 1236-41. DOI: 10.1038/ng.3406

Correction: Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate.
Andreassen, O. A., Thompson, W. K., Schork, A. J., Ripke, S., Mattingsdal, M., Kelsoe, J. R., … Psychiatric Genomics Consortium (PGC) (2015).
P L o S Genetics (Online), 11(11), e1005544. DOI: 10.1371/journal.pgen.1005544

Partitioning heritability by functional annotation using genome-wide association summary statistics.
Finucane, H. K., Bulik-Sullivan, B., Gusev, A., Trynka, G., Reshef, Y., Loh, P-R., … ReproGen Consortium (2015).
Nature Genetics, 47(11), 1228-35. DOI: 10.1038/ng.3404

Population genetic differentiation of height and body mass index across Europe.
Robinson, M. R., Hemani, G., Medina-Gomez, C., Mezzavilla, M., Esko, T., Shakhbazov, K., … Visscher, P. M. (2015).
Nature Genetics, 47(11), 1357-62. DOI: 10.1038/ng.3401

Genetic Markers of Human Evolution Are Enriched in Schizophrenia.
Srinivasan, S., Bettella, F., Mattingsdal, M., Wang, Y., Witoelar, A., Schork, A. J., … Schizophrenia Working Group of the Psychiatric Genomics Consortium, The International Headache Genetics Consortium (2015).
Biological Psychiatry. DOI: 10.1016/j.biopsych.2015.10.009

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores.
Vilhjálmsson, B. J., Yang, J., Finucane, H. K., Gusev, A., Lindström, S., Ripke, S., … Schizophrenia Working Group of the Psychiatric Genomics Consortium (2015).
American Journal of Human Genetics, 97(4), 576-92. DOI: 10.1016/j.ajhg.2015.09.001

Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case–control sample of schizophrenia.
Ingason, A., Giegling, I., Harmann, A. M., Genius, J., Konte, B., Fried, M., … Olsen, L. (2015).
Translational Psychiatry, 5(10), e656. DOI: 10.1038/tp.2015.151

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis.
Lee, S. H., Byrne, E. M., Hultman, C. M., Kähler, A., Vinkhuyzen, A. A., Ripke, S., … Schizophrenia Working Group of the Psychiatric Genomics Consortium and Rheumatoid Arthritis Consortium International (2015).
International Journal of Epidemiology, 44(5), 1706-1721. DOI: 10.1093/ije/dyv136

Risk factors and mortality among patients with severe muco-cutaneous drug reactions.
Crüger, A-M. T., Kaur-Knudsen, D., Zachariae, C., Rasmussen, H. B., & Thomsen, S. F. (2015).
Danish Medical Bulletin (Online), 62(8), [A5122].

Genetic characterization of blood spot-derived DNA from 209 individuals known to carry 22q11Del reveals a new nested deletion.
Sparsø, T. H. (2015).
European journal of human genetics : EJHG, (PS09.003).

Evaluating historical candidate genes for schizophrenia.
Farrell, M. S., Werge, T., Sklar, P., Owen, M. J., Ophoff, R. A., O’Donovan, M. C., … Sullivan, P. F. (2015).
Molecular Psychiatry, 20(5), 555-62. DOI: 10.1038/mp.2015.16

Individualization of treatments with drugs metabolized by CES1: combining genetics and metabolomics.
Rasmussen, H. B., Bjerre, D., Linnet, K., Jürgens, G., Dalhoff, K., Stefansson, H., … Kaalund-Brok, K. (2015).
Pharmacogenomics, 16(6), 649-665. DOI: 10.2217/pgs.15.7

Antipsychotic-Like Effect of the Muscarinic Acetylcholine Receptor Agonist BuTAC in Non-Human Primates.
Andersen, M. B., Croy, C. H., Dencker, D., Werge, T., Bymaster, F. P., Felder, C. C., & Fink-Jensen, A. (2015).
P L o S One, 10(4), e0122722. DOI: 10.1371/journal.pone.0122722

Comment on Xie et al.: The effects of CES1A2 A(-816)C and CYP2C19 loss-of-function polymorphisms on clopidogrel response variability among Chinese patients with coronary heart disease.
Bjerre, D., Ferrero, L., Madsen, M., Hansen, P. R., Rasmussen, H. B., INDICES Consortium, … Pagsberg, A. K. (2015).
Pharmacogenetics and Genomics, 25(3), 147. DOI: 10.1097/FPC.0000000000000114

Genetics of Complex Traits and Disorders Discovery and impact of rare variants.
Thygesen, J. H. (2015).

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies.
Bulik-Sullivan, B. K., Loh, P-R., Finucane, H. K., Ripke, S., Yang, J., Patterson, N., … Schizophrenia Working Group of the Psychiatric Genomics Consortium (2015).
Nature Genetics, 47(3), 291-5. DOI: 10.1038/ng.3211

Mining of hospital laboratory information systems: a model study defining age- and gender-specific reference intervals and trajectories for plasma creatinine in a pediatric population.
Søeby, K., Jensen, P. B., Werge, T., & Sørensen, S. (2015).
Clinical Chemistry and Laboratory Medicine. DOI: 10.1515/cclm-2014-0949

Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder.
Maier, R., Moser, G., Chen, G-B., Ripke, S., Coryell, W., Potash, J. B., … Cross-Disorder Working Group of the Psychiatric Genomics Consortium (2015).
American Journal of Human Genetics, 96(2), 283-94. DOI: 10.1016/j.ajhg.2014.12.006

Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers in Patients With Abdominal Aortic Aneurysms: Nation-Wide Cohort Study.
Kristensen, K. E., Torp-Pedersen, C., Gislason, G. H., Egfjord, M., Rasmussen, H. B., & Hansen, P. R. (2015).
Arteriosclerosis, Thrombosis, and Vascular Biology, 35(3), 733-40. DOI: 10.1161/ATVBAHA.114.304428

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways.
The Network and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium (2015).
Nature Neuroscience. DOI: 10.1038/nn.3922

A nation-wide study of the family aggregation and risk factors in anorexia nervosa over three generations.
Steinhausen, H-C., Jakobsen, H., Helenius, D., Munk-Jørgensen, P., & Strober, M. (2015).
International Journal of Eating Disorders, 48(1), 1-8. DOI: 10.1002/eat.22293

Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons.
Mellerup, E., Andreassen, O. A., Bennike, B., Dam, O. H., Djurovic, S., Hansen, T., … Moeller, G. L. (2015).
P L o S One, 10(11), e0143432. DOI: 10.1371/journal.pone.0143432

Danish Central Cytogenetic Register: Population-based survival analysis of mental disorders among carriers of chromosomal abnormalities.
Høffding, L. K. E. (2015).
American Society of Human Genetics.

Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci.
Andreassen, O. A., Harbo, H. F., Wang, Y., Thompson, W. K., Schork, A. J., Mattingsdal, M., … The Psychiatric Genomics Consortium (PGC) Bipolar Disorder and Schizophrenia Work Groups (2015).
Molecular Psychiatry, 20(2), 207-214. DOI: 10.1038/mp.2013.195

Pharmacogenetic Risk Stratification in Angiotensin-Converting Enzyme Inhibitor-Treated Patients with Congestive Heart Failure: A Retrospective Cohort Study.
Nelveg-Kristensen, K. E., Busk Madsen, M., Torp-Pedersen, C., Køber, L., Egfjord, M., Berg Rasmussen, H., & Riis Hansen, P. (2015).
P L o S One, 10(12), e0144195. DOI: 10.1371/journal.pone.0144195

Soluble Urokinase-Type Plasminogen Activator Receptor Levels in Patients With Schizophrenia.
Nielsen, J., Røge, R., Pristed, S. G., Viuff, A. G., Ullum, H., Thørner, L. W., … Vang, T. (2015).
Schizophrenia Bulletin, 41(3), e764-71. DOI: 10.1093/schbul/sbu118

Synthetic cannabimimetic agents metabolized by carboxylesterases.
Thomsen, R., Nielsen, L. M., Holm, N. B., Rasmussen, H. B., Linnet, K., the INDICES Consortium, … Pagsberg, A. K. (2015).
Drug Testing and Analysis. DOI: 10.1002/dta.1731

The Danish 22q11 research initiative.
Schmock, H., Vangkilde, A., Larsen, K. M., Fischer, E., Birknow, M. R., Jepsen, J. R. M., … Olsen, L. (2015).
B M C Psychiatry, 15(1), 220. DOI: 10.1186/s12888-015-0594-7

Usefulness of the SNP microarray technology to identify rare mutations in the case of perinatal death.
Hoeffding, L. K., Kock, K. F., Johnsen, I. G., Hansen, T., & Werge, T. (2015).
Case Reports in Perinatal Medicine.

 

2014

Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases.
Gusev, A., Lee, S. H., Trynka, G., Finucane, H., Vilhjálmsson, B. J., Xu, H., … Werge, T. M. (2014).
American Journal of Human Genetics, 95(5), 535-52. DOI: 10.1016/j.ajhg.2014.10.004

Predicting ADHD in school age when using the Strengths and Difficulties Questionnaire in preschool age: a longitudinal general population study, CCC2000.
Rimvall, M. K., Elberling, H., Rask, C. U., Helenius, D., Skovgaard, A. M., & Jeppesen, P. (2014).
European Child & Adolescent Psychiatry, 23(11). DOI: 10.1007/s00787-014-0546-7

3D facial landmarks: Inter-operator variability of manual annotation.
Fagertun, J., Harder, S., Rosengren, A., Moeller, C., Werge, T., Paulsen, R. R., & Hansen, T. (2014).
BMC Medical Imaging, 14(1), 35. DOI: 10.1186/1471-2342-14-35

Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.
Ruderfer, D. M., Fanous, A. H., Ripke, S., McQuillin, A., Amdur, R. L., Gejman, P. V., … Schizophrenia Working Group of Psychiatric Genomics Consortium (2014).
Molecular Psychiatry, 19(9), 1017-24. DOI: 10.1038/mp.2013.138

Biological insights from 108 schizophrenia-associated genetic loci.
Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014).
Nature, 511(7510), 421-7. DOI: 10.1038/nature13595

Variability in working memory performance explained by epistasis vs polygenic scores in the ZNF804A pathway.
Schizophrenia Psychiatric Genome-wide Association Study (GWAS) Consortium, & PGC schizophrenia working group (Thomas M Werge, Thomas Folkmann Hansen, members) (2014).
JAMA Psychiatry, 71(7), 778-85. DOI: 10.1001/jamapsychiatry.2014.528

The one and the many: effects of the cell adhesion molecule pathway on neuropsychological function in psychosis.
Hargreaves, A., Anney, R., O’Dushlaine, C., Nicodemus, K. K., Gill, M., Corvin, A., … Schizophrenia Psychiatric Genome-Wide Association Study Consortium (PGC-SCZ) (2014).
Psychological medicine, 44(10), 2177-87. DOI: 10.1017/S0033291713002663

Erratum to: Dose-Specific Adverse Drug Reaction Identification in Electronic Patient Records: Temporal Data Mining in an Inpatient Psychiatric Population
Eriksson, R., Werge, T., Jensen, L. J., & Brunak, S.
DOI: 10.1007/s40264-014-0158-7

Concordance Rates and Heritability in Schizophrenia, Data from a Danish Twin Cohort.
Hilker, R., Helenius, D., Fagerlund, B., Skytte, A., Nordentoft, M., & Glenthøj, B. Y. (2014).
Schizophrenia Research, 153(Suppl. 1), 322.

Metabolomics has the potential to improve drug therapy.
Stage, C., Jürgens, G., Dalhoff, K. P., & Rasmussen, H. B. (2014).
Ugeskrift for læger [online], 176(6).

Dose-Specific Adverse Drug Reaction Identification in Electronic Patient Records: Temporal Data Mining in an Inpatient Psychiatric Population.
Eriksson, R., Werge, T., Jensen, L. J., & Brunak, S. (2014).
Drug Safety, 37(4), 237-247. DOI: 10.1007/s40264-014-0145-z

Are TMEM genes potential candidate genes for panic disorder?
Gregersen, N., Buttenschøn, H. N., Hedemand, A., Dahl, H. A., Kristensen, A. S., Clementsen, B., … Mors, O. (2014).
Psychiatric Genetics, 24(1), 37-41. DOI: 10.1097/YPG.0000000000000022

CNVs conferring risk of autism or schizophrenia affect cognition in controls.
Stefansson, H., Meyer-Lindenberg, A., Steinberg, S., Magnusdottir, B., Morgen, K., Arnarsdottir, S., … Stefansson, K. (2014).
Nature, 505(7483), 361-6. DOI: 10.1038/nature12818

Introducing the hypothome: a way to integrate predicted proteins in interactomes.
Desler, C., Zambach, S., Suravajhala, P., & Rasmussen, L. J. (2014).
International Journal of Bioinformatics Research and Applications, 10(6), 647-52. DOI: 10.1504/IJBRA.2014.065247

In vitro drug metabolism by human carboxylesterase 1: focus on angiotensin-converting enzyme inhibitors.
Thomsen, R., Rasmussen, H. B., Linnet, K., & INDICES Consortium (2014).
Drug Metabolism and Disposition, 42(1), 126-33. DOI: 10.1124/dmd.113.053512

Sequence analysis of 17 NRXN1 deletions.
Hoeffding, L. K. E., Hansen, T., Ingason, A., Doung, L., Thygesen, J. H., Møller, R. S., … Werge, T. (2014).
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 165(1), 52-61. DOI: 10.1002/ajmg.b.32204

A Mouse Model that Recapitulates Cardinal Features of the 15q13.3 Microdeletion Syndrome Including Schizophrenia- and Epilepsy-Related Alterations.
Fejgin, K., Nielsen, J., Birknow, M. R., Bastlund, J. F., Nielsen, V., Lauridsen, J. B., … Didriksen, M. (2014).
Biological Psychiatry, 76(2), 128-137. DOI: 10.1016/j.biopsych.2013.08.014

Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
Goldstein, J. I., Fredrik Jarskog, L., Hilliard, C., Alfirevic, A., Duncan, L., Fourches, D., … Sullivan, P. F. (2014).
Nature Communications, 5, 4757. DOI: 10.1038/ncomms5757

Common variant at 16p11.2 conferring risk of psychosis.
Steinberg, S., de Jong, S., Mattheisen, M., Costas, J., Demontis, D., Jamain, S., … GROUP (2014).
Molecular Psychiatry, 19, 108–114. DOI: 10.1038/mp.2012.157

EHMTI-0377. The influence of genetic constitution on migraine drug responses.
Christensen, A. F., Esserlind, A. L., Werge, T., Stefansson, H., & Olesen, J. (2014).
Journal of Headache and Pain, 15(1), 1-1.

EHMTI-0380. The association of migraine susceptibility loci with severe migraine characteristics in a clinic-based migraine sample.
Esserlind, A., Christensen, A. F., Steinberg, S., Grarup, N., Pedersen, O., Hansen, T., … Olesen, J. (2014).
Journal of Headache and Pain, 15(1), 1-1.

Erratum: Sequence analysis of 17 NRXN1 deletions
Hoeffding, L. K., Hansen, T., Ingason, A., Duong, L., Thygesen, J. H., Møller, R. S., … Larsen, L. A.

Family load estimates and risk factors of anxiety disorders in a nationwide three generation study.
Helenius, D., Munk-Jørgensen, P., & Steinhausen, H-C. (2014).
Psychiatry Research, 216(3), 351-356. DOI: 10.1016/j.psychres.2014.02.026

Genetic and clinical characterization of neuropsychiatric patients with copy numbers variations.
Duong, L. (2014).
University of Copenhagen.

Negation scope and spelling variation for text-mining of Danish electronic patient records.
Thomas, C. E., Jensen, P. B., Werge, T., & Brunak, S. (2014).
Proceedings of the 5th International Workshop on Health Text Mining and Information Analysis (Louhi)@ EACL, 64-68.

 

2013

A genetic deconstruction of neurocognitive traits in schizophrenia and bipolar disorder.
Fernandes, C. P. D., Christoforou, A., Giddaluru, S., Ersland, K. M., Djurovic, S., Mattheisen, M., … Genetic Risk and Outcome of Psychosis (GROUP) (2013).
P L o S One, 8(12), e81052. DOI: 10.1371/journal.pone.0081052

Family aggregation and risk factors of obsessive-compulsive disorders in a nationwide three-generation study.
Steinhausen, H-C. E., Bisgaard, C., Munk-Jørgensen, P., & Helenius, D. (2013).
Depression and Anxiety (Hoboken), 30(12), 1177-84. DOI: 10.1002/da.22163

Schizophrenia genetic variants are not associated with intelligence.
van Scheltinga, A. F. T., Bakker, S. C., van Haren, N. E. M., Derks, E. M., Buizer-Voskamp, J. E., Cahn, W., … Psychiatric Genome-Wide Association Study (GWAS) Consortium (2013).
Psychological Medicine, 143(12), 2563-2570. DOI: 10.1017/S0033291713000196

Does Pharmacogenetic Testing for CYP450 2D6 and 2C19 among Patients with Diagnoses within the Schizophrenic Spectrum Reduce Treatment Costs?
Herbild, L., Andersen, S. E., Werge, T., Rasmussen, H. B., & Jürgens, G. (2013).
Basic & Clinical Pharmacology & Toxicology Online, 113(4), 266-272. DOI: 10.1111/bcpt.12093

Psykiatrisk forskning bør have en central plads i langsigtede planer for psykiatrien.
Nordentoft, M., Glenthøj, B., Kessing, L. V., Parnas, J., Werge, T., Bech, P., … Seinhausen, C. (2013).
Ugeskrift for laeger, 175(36), 2056-7.

Genetic analyses of the human eye colours using a novel objective method for eye colour classification.
Andersen, J. D., Johansen, J. P., Harder, S., Christoffersen, S. R., Delgado, M. C., Henriksen, S. T., … Morling, N. (2013).
Forensic Science International: Genetics. Supplement Series, 7(5), 508-15. DOI: 10.1016/j.fsigen.2013.05.003

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.
Lee, S. H., Ripke, S., Neale, B. M., Faraone, S. V., Purcell, S. M., Perlis, R. H., … Cross-Disorder Group of the Psychiatric Genomics Consortium (2013).
Nature Genetics, 984-994. DOI: 10.1038/ng.2711

A comprehensive family-based replication study of schizophrenia genes.
Aberg, K. A., Liu, Y., Bukszár, J., McClay, J. L., Khachane, A. N., Andreassen, O. A., … van den Oord, E. J. (2013).
JAMA Psychiatry, 70(6), 573-81.

Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC.
Hamshere, M. L., Walters, J. T. R., Smith, R., Richards, A., Green, E., Grozeva, D., … The Schizophrenia Psychiatric Genome-wide Association Study Consortium (PGC), Wellcome Trust Case Control Consortium+ (WTCCC+), Wellcome Trust Case Control Consortium 2 (WTCCC2) (2013).
Molecular Psychiatry, 18(6), 708-712. DOI: 10.1038/mp.2012.67

Neuropeptide Y genes and suicidal behaviour among schizophrenic patients. Psychiatric Genetics, 23(3), 139-140. DOI: 10.1097/YPG.0b013e32835d70ed
Wang, A. G., Koefoed, P., Jacoby, A. S., Woldbye, D., Rasmussen, H. B., Timm, S., … Werge, T. (2013).

Replication and meta-analysis of common variants identifies a genome-wide significant locus in migraine.
Esserlind, A. L., Christensen, A. F., Le, H., Kirchmann, M., Hauge, A. W., Toyserkani, N. M., … Olesen, J. (2013).
European Journal of Neurology, 765-772. DOI: 10.1111/ene.12055

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
Cross-Disorder Group of the Psychiatric Genomics Consortium (2013).
Lancet, 381(9875), 1371-9. DOI: 10.1016/S0140-6736(12)62129-1

Redox Dysregulation in the Pathophysiology of Schizophrenia and Bipolar Disorder: Insights from Animal Models.
Kulak, A., Steullet, P., Cabungcal, J-H., Werge, T., Ingason, A., Cuenod, M., & Do, K. Q. (2013).
Antioxidants & Redox Signaling, 18(12), 1428-1443. DOI: 10.1089/ars.2012.4858

3D gender recognition using cognitive modeling.
Fagertun, J., Andersen, T., Hansen, T. F., & Reinhold Paulsen, R. (2013).
International workshop on biometrics and forensics. DOI: 10.1109/IWBF.2013.6547324

All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs.: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs.
Tobacco and Genetics Consortium, & The Schizophrenia Psychiatric Genomics Consortium (2013).
P L o S Genetics (Online), 9(4), e1003449. DOI: 10.1371/journal.pgen.1003449

Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate.
Andreassen, O. A., Thompson, W. K., Schork, A. J., Ripke, S., Mattingsdal, M., Kelsoe, J. R., … Psychiatric Genomics Consortium (PGC) (2013).
P L o S Genetics (Online), 9(4), e1003455. DOI: 10.1371/journal.pgen.1003455

Genetisk variation i effekten af clopidogrel.
Kristensen, K. E., Rasmussen, H. B., & Hansen, P. R. (2013).
Ugeskrift for Laeger, 175(11), 729-32.

Enhanced maternal origin of the 22q11.2 deletion in velocardiofacial and DiGeorge syndromes.
Delio, M., Guo, T., McDonald-McGinn, D. M., Zackai, E., Herman, S., Kaminetzky, M., … Morrow, B. E. (2013).
American Journal of Human Genetics, 92(3), 439-47. DOI: 10.1016/j.ajhg.2013.01.018

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.
Albrechtsen, A., Grarup, N., Li, Y., Sparsø, T., Tian, G., Cao, H., … D.E.S.I.R. Study Group (2013).
Diabetologia, 56(2), 298-310. DOI: 10.1007/s00125-012-2756-1

Improved Detection of Common Variants Associated with Schizophrenia by Leveraging Pleiotropy with Cardiovascular-Disease Risk Factors.
International Consortium for Blood Pressure GWAS, & Psychiatric Genomics Consortium Schizophrenia Working Group (2013).
American Journal of Human Genetics, 92(2), 197-209. DOI: 10.1016/j.ajhg.2013.01.001

Carboxylesterase 1 gene duplication and mRNA expression in adipose tissue are linked to obesity and metabolic function.
Friedrichsen, M., Poulsen, P. H., Wojtaszewski, J., Hansen, P. R., Vaag, A., & Rasmussen, H. B. (2013).
P L o S One, 8(2), e56861. DOI: 10.1371/journal.pone.0056861

Den genetiske hjerne.
Tommerup, N., Christensen, K., & Werge, T. M. (2013).
I Den genetiske hjerne Hjerneforum.

Does routine CYP2D6 and CYP2C19 genotyping reduce the risk of adverse events related to antipsychotic drug treatment?
Jürgens, G., Andersen, S. E., Jensen, H., Rasmussen, H. B., Werge, T. M., & Nordentoft, M. (2013).
Clinical Toxicology, 51(4), 325-325.

Genetic Schizophrenia Risk Variants Jointly Modulate Total Brain and White Matter Volume.
Terwisscha van Scheltinga, A. F., Bakker, S. C., van Haren, N. E. M., Derks, E. M., Buizer-Voskamp, J. E., Boos, H. B. M., … the Psychiatric Genome-wide Association Study Consortium (2013).
Advances in Biological Psychiatry, 73(6), 525-531. DOI: 10.1016/j.biopsych.2012.08.017

Genome-Wide Association Study of Genetic Variants in LPS-Stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-α Cytokine Response in a Danish Cohort.
Larsen, M. H., Albrechtsen, A., Thørner, L. W., Werge, T., Hansen, T., Gether, U., … Ullum, H. (2013).
P L o S One, 8(6), e66262. DOI: 10.1371/journal.pone.0066262

Hjernen – Genetik og Udvikling i Billeder.
Baruël Johansen, L., Siebner, H. R., Werge, T. M., & Madsen, K. S. (2013).
I N. Tommerup (red.), Den Genetiske Hjerne (Bind 2013, s. 23-34). Hjerneforum.

Predicting ADHD in school age children when using the Strengths and Difficulties Questionnaire in preschool: a longitudinal general population study.
Rimvall, M., Elberling, H., Rask, C. U., Helenius, D., Skovgaard, A. M., & Jeppesen, P. (2013).
Abstract fra Region Hovedstadens Psykiatris Forskningsdag, København, Danmark.

Risk of hemorrhagic events in patients co-treated with clopidogrel and angiotensin-converting enzyme inhibitors after myocardial infarction.
Kristensen, K. E., Gislason, G. H., Torp-Pedersen, C., Rasmussen, H. B., & Hansen, P. R. (2013).
Eur.Heart J., 34(Suppl. 1), 471, No. P2513.

The pedictive validity of the strengths and difficulties questionnaire (SDQ) in preschool children with regard to ADHD diagnosis in scool age: a register based study.
Rimvall, M., Elberling, H., Clemmensen, L., Munkholm, A., Rask, C. U., Helenius, D., … Jeppesen, P. (2013).
Abstract fra European Society for Child and Adolescent Psychiatry, Irland.

 

2012

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and age at onset of schizophrenia: No consistent evidence for an association in the nordic population.
Saetre, P., Grove, J., Børglum, A., Mors, O., Werge, T., Andreassen, O. A., … Jönsson, E. G. (2012).
American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 159B(8), 981-6. DOI: 10.1002/ajmg.b.32104

Lack of association between the regulator of G-protein signaling 4 (RGS4) rs951436 polymorphism and schizophrenia.
Jönsson, E. G., Saetre, P., Nyholm, H., Djurovic, S., Melle, I., Andreassen, O. A., … Terenius, L. (2012).
Psychiatric Genetics, 22(5), 263-4. DOI: 10.1097/YPG.0b013e32834f3558

Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe.
Rietschel, M., Mattheisen, M., Degenhardt, F., Kahn, R. S., Linszen, D. H., Os, J. V., … GROUP Investigators (2012).
Molecular Psychiatry, 17(9), 906-917. DOI: 10.1038/mp.2011.80

Genome-wide association study of multiplex schizophrenia pedigrees.
Levinson, D. F., Shi, J., Wang, K., Oh, S., Riley, B., Pulver, A. E., … Schizophrenia Psychiatric GWAS Consortium (2012).
The American journal of psychiatry, 169(9), 963-73. DOI: 10.1176/appi.ajp.2012.11091423

Genome-wide identification of structural variants in genes encoding drug targets: possible implications for individualized drug therapy.
Rasmussen, H. B., & Dahmcke, C. M. (2012).
Pharmacogenetics and Genomics, 22(7), 471-83. DOI: 10.1097/FPC.0b013e328352c770

No association of polymorphisms in human endogenous retrovirus K18 and CD48 with schizophrenia.
Nyegaard, M., Demontis, D., Thestrup, B. B., Hedemand, A., Sørensen, K. M., Hansen, T., … Børglum, A. (2012).
Psychiatric Genetics, 22(3), 146-8. DOI: 10.1097/YPG.0b013e328353953c

Association between a genetic variant in the serotonin transporter gene (SLC6A4) and suicidal behavior in patients with schizophrenia.
Lindholm Carlstrom, E., Saetre, P., Rosengren, A., Thygesen, J. H., Djurovic, S., Melle, I., … Jönsson, E. G. (2012).
Behavioral and Brain Functions, 8(1). DOI: 10.1186/1744-9081-8-24

The gene encoding the melanin-concentrating hormone receptor 1 is associated with schizophrenia in a Danish case-control sample.
Demontis, D., Nyegaard, M., Christensen, J. H., Severinsen, J. E., Hedemand, A., Hansen, T., … Børglum, A. (2012).
Psychiatric Genetics, 22(2), 62-9. DOI: 10.1097/YPG.0b013e32834dc424

Don’t give up on GWAS.
Sullivan, P., & 96 Psychiatric Genetics Investigators (2012).
Molecular Psychiatry, 17(1), 2-3. DOI: 10.1038/mp.2011.94

Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression.
Koefoed, P., Woldbye, D. P. D., Hansen, T. V. O., Eplov, L. F., Christiansen, S. H., Mors, O., … Bolwig, T. G. (2012).
Acta Neuropsychiatrica, 24(2), 81-90. DOI: 10.1111/j.1601-5215.2011.00600.x

Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia.
Carrera, N., Arrojo, M., Sanjuán, J., Ramos-Ríos, R., Paz, E., Suárez-Rama, J. J., … Costas, J. (2012).
Biological Psychiatry, 71(2), 169-77. DOI: 10.1016/j.biopsych.2011.09.032

Connection between Genetic and Clinical Data in Bipolar Disorder.
Mellerup, E., Andreassen, O., Bennike, B., Dam, O. H., Durovic, S., Hansen, T., … Koefoed, P. (2012).
P L o S One, 7(9), e44623. DOI: 10.1371/journal.pone.0044623

D-amino acid oxidase activator gene (DAOA) variation affects cerebrospinal fluid homovanillic acid concentrations in healthy Caucasians.
Andreou, D., Saetre, P., Werge, T., Andreassen, O. A., Agartz, I., Sedvall, G. C., … Jönsson, E. G. (2012).
European Archives of Psychiatry and Clinical Neuroscience, 262(7), 549-56. DOI: 10.1007/s00406-012-0313-z

DCLK1 variants are associated across schizophrenia and attention deficit/hyperactivity disorder.
Håvik, B., Degenhardt, F. A., Johansson, S., Fernandes, C. P. D., Hinney, A., Scherag, A., … Le Hellard, S. (2012).
P L o S One, 7(4), e35424. DOI: 10.1371/journal.pone.0035424

Does the Medication Pattern Reflect the CYP2D6 Genotype in Patients With Diagnoses Within the Schizophrenic Spectrum?
Jürgens, G., Rasmussen, H. B., Werge, T., Dalhoff, K., Nordentoft, M., & Andersen, S. E. (2012).
Journal of Clinical Psychopharmacology, 32(1), 100-5. DOI: 10.1097/JCP.0b013e31823f6b6a

Enantioselective determination of methylphenidate and ritalinic acid in whole blood from forensic cases using automated solid-phase extraction and liquid chromatography-tandem mass spectrometry.
Thomsen, R., Rasmussen, H. B., Linnet, K., & INDICES Consortium (2012).
Journal of Analytical Toxicology, 36(8), 560-8. DOI: 10.1093/jat/bks065

Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs.
Lee, S. H., DeCandia, T. R., Ripke, S., Yang, J., Sullivan, P. F., Goddard, M. E., … Werge, T. M. (2012).
Nature Genetics, 44(3), 247-50. DOI: 10.1038/ng.1108

Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes.
de Jong, S., van Eijk, K. R., Zeegers, D. W. L. H., Strengman, E., Janson, E., Veldink, J. H., … PGC Schizophrenia (GWAS) Consortium (2012).
European Journal of Human Genetics, 20(9), 1004-8. DOI: 10.1038/ejhg.2012.38

Gene-Based Analysis of Regionally Enriched Cortical Genes in GWAS Data Sets of Cognitive Traits and Psychiatric Disorders.
Ersland, K. M., Christoforou, A., Stansberg, C., Espeseth, T., Mattheisen, M., Mattingsdal, M., … Le Hellard, S. (2012).
P L o S One, 7(2), e31687. DOI: 10.1371/journal.pone.0031687

Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms.
Fanous, A. H., Zhou, B., Aggen, S. H., Bergen, S. E., Amdur, R. L., Duan, J., … Rasmussen, H. B. (2012).
American Journal of Psychiatry, 169(12), 1309-17. DOI: 10.1176/appi.ajp.2012.12020218

Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis.
Derks, E. M., Vorstman, J. A. S., Ripke, S., Kahn, R. S., Ophoff, R. A., & Schizophrenia Psychiatric Genomic Consortium (2012).
P L o S One, 7(6), e37852. DOI: 10.1371/journal.pone.0037852

Kynurenine 3-monooxygenase polymorphisms: relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls.
Holtze, M., Saetre, P., Engberg, G., Schwieler, L., Werge, T., Andreassen, O. A., … Erhardt, S. (2012).
Journal of Psychiatry and Neuroscience, 37(1), 53-7. DOI: 10.1503/jpn.100175

Mutations in NRXN1 in a family multiply affected with brain disorders: NRXN1 mutations and brain disorders.
Duong, L., Klitten, L. L., Møller, R. S., Ingason, A., Jakobsen, K. D., Skjødt, C., … Tommerup, N. (2012).
American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 159B(3), 354-8. DOI: 10.1002/ajmg.b.32036

Promoter variants in IL18 are associated with onset of depression in patients previously exposed to stressful-life events.
Haastrup, E., Bukh, J. O. D., Bock, C., Vinberg, M., Thørner, L. W., Hansen, T., … Ullum, H. (2012).
Journal of Affective Disorders, 136(1-2), 134-8. DOI: 10.1016/j.jad.2011.08.025

Replication study and meta-analysis in European samples supports association of the 3p21.1 locus with bipolar disorder.
Vassos, E., Steinberg, S., Cichon, S., Breen, G., Sigurdsson, E., Andreassen, O. A., … GROUP Consortium (2012).
Biological Psychiatry, 72(8), 645-50. DOI: 10.1016/j.biopsych.2012.02.040

Response to Boot et al. Letter.
Werge, T., Ingason, A., Kirov, G., Rujescu, D., & Sigurdsson, E. (2012).
American Journal of Psychiatry, 169(1), 97. DOI: 10.1176/appi.ajp.2011.11091382r

Restriction Fragment Length Polymorphism Analysis of PCR-Amplified Fragments(PCR-RFLP) and Gel Electrophoresis – Valuable Tool for Genotyping and Genetic Fingerprinting. I S. Magdeldin (red.),
Rasmussen, H. B. (2012).
GEL ELECTROPHORESIS – PRINCIPLES AND BASICS (s. 315-334). Rijeka, Kroatien: InTech.

Runs of homozygosity implicate autozygosity as a schizophrenia risk factor.
Keller, M. C., Simonson, M. A., Ripke, S., Neale, B. M., Gejman, P. V., Howrigan, D. P., … Schizophrenia Psychiatric Genome-Wide Association Study Consortium (2012).
P L o S Genetics, 8(4), e1002656. DOI: 10.1371/journal.pgen.1002656

Screening of congenital heart disease patients using multiplex ligation-dependent probe amplification: early diagnosis of syndromic patients.
Sørensen, K. M., El-Segaier, M., Fernlund, E., Errami, A., Bouvagnet, P., Nehme, N., … Larsen, L. A. (2012).
American Journal of Medical Genetics. Part A, 158A(4), 720-5. DOI: 10.1002/ajmg.a.35214

Utility and adoption of CYP2D6 and CYP2C19 genotyping and its translation into psychiatric clinical practice.
Jürgens, G., Jacobsen, C. B., Rasmussen, H. B., Werge, T. M., Nordentoft, M., & Andersen, S. E. (2012).
Acta Psychiatrica Scandinavica, 125(3), 228-37. DOI: 10.1111/j.1600-0447.2011.01802.x

 

2011

Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples.
Tesli, M., Koefoed, P., Athanasiu, L., Mattingsdal, M., Gustafsson, O., Agartz, I., … Andreassen, O. A. (2011).
American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 156(8), 969-74. DOI: 10.1002/ajmg.b.31244

Association of GRIN1 and GRIN2A-D With schizophrenia and genetic interaction with maternal herpes simplex virus-2 infection affecting disease risk.
Demontis, D., Nyegaard, M., Buttenschøn, H. N., Hedemand, A., Pedersen, C. B., Grove, J., … Mortensen, P. B. (2011).
American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 156(8), 913-22. DOI: 10.1002/ajmg.b.31234

Common variants on 8p12 and 1q24.2 confer risk of schizophrenia.
Shi, Y., Li, Z., Xu, Q., Wang, T., Li, T., Shen, J., … He, L. (2011).
Nature Genetics, 43(12), 1224-7. DOI: 10.1038/ng.980

Copy number variations in affective disorders and meta-analysis.
Olsen, L., Hansen, T., Djurovic, S., Haastrup, E., Albrecthsen, A., Høffding, L. K. E., … Werge, T. M. (2011).
Psychiatric Genetics, 21(6), 319-22. DOI: 10.1097/YPG.0b013e3283463deb

Genome-wide association study identifies five new schizophrenia loci.
Ripke, S., Sanders, A. R., Kendler, K. S., Levinson, D. F., Sklar, P., Holmans, P. A., … Hansen, T. F. (2011).
Nature Genetics, 43, 969-976. DOI: 10.1038/ng.940

Genome-wide association study identifies four loci associated with eruption of permanent teeth.
Geller, F., Feenstra, B., Zhang, H., Shaffer, J. R., Hansen, T., Esserlind, A-L., … Melbye, M. (2011).
P L o S Genetics, 7(9), e1002275. DOI: 10.1371/journal.pgen.1002275

Dystrobrevin-binding protein 1 gene (DTNBP1) variants associated with cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentrations in healthy volunteers.
Andreou, D., Saetre, P., Kähler, A. K., Werge, T., Andreassen, O. A., Agartz, I., … Jönsson, E. G. (2011).
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 21(9), 700-4. DOI: 10.1016/j.euroneuro.2010.12.008

Combinations of SNPs related to signal transduction in bipolar disorder.
Koefoed, P., Andreassen, O. A., Bennike, B., Dam, H., Djurovic, S., Hansen, T., … Mellerup, E. (2011).
P L o S One, 6(8), e23812. DOI: 10.1371/journal.pone.0023812

Lack of association between two dopamine D2 receptor gene polymorphisms and schizophrenia.
Caprini, S., Saetre, P., Melle, I., Djurovic, S., Andreassen, O. A., Skjødt, C., … Jönsson, E. G. (2011).
Psychiatric Genetics, 21(4), 214-5. DOI: 10.1097/YPG.0b013e328341e020

Using electronic patient records to discover disease correlations and stratify patient cohorts.
Roque, F. S., Jensen, P. B., Schmock, H., Dalgaard, M., Andreatta, M., Hansen, T., … Brunak, S. (2011).
P L o S Computational Biology, 7(8), e1002141. DOI: 10.1371/journal.pcbi.1002141

Common Variants at VRK2 and TCF4 Conferring Risk of Schizophrenia.
Steinberg, S., de Jong, S., Andreassen, O. A., Werge, T., Børglum, A., Mors, O., … Irish Schizophrenia Genomics Consortium (2011).
Human Molecular Genetics, 20(20), 4076-4081. DOI: 10.1093/hmg/ddr325

At-Risk Variant in TCF7L2 for Type II Diabetes Increases Risk of Schizophrenia.
Hansen, T., Ingason, A., Djurovic, S., Melle, I., Fenger, M., Gustafsson, O., … Werge, T. (2011).
Biological Psychiatry, 70(1), 59-63. DOI: 10.1016/j.biopsych.2011.01.031

A rare variant in MYH6 is associated with high risk of sick sinus syndrome.
Holm, H., Gudbjartsson, D. F., Sulem, P., Masson, G., Helgadottir, H. T., Zanon, C., … Stefansson, K. (2011).
Nature Genetics, 43(4), 316-20. DOI: 10.1038/ng.781

Maternally Derived Microduplications at 15q11-q13: Implication of Imprinted Genes in Psychotic Illness.
Ingason, A., Kirov, G., Giegling, I., Hansen, T., Isles, A. R., Jakobsen, K. D., … GROUP Investigators (2011).
American Journal of Psychiatry, 168(4), 408-417. DOI: 10.1176/appi.ajp.2010.09111660

Kynurenine 3-monooxygenase (KMO) polymorphisms in schizophrenia: An association study.
Holtze, M., Saetre, P., Erhardt, S., Schwieler, L., Werge, T., Hansen, T., … Schalling, M. (2011).
Schizophrenia research, 127(1-3), 270-2. DOI: 10.1016/j.schres.2010.10.002

Do guidelines recommending pharmacogenetic testing of psychiatric patients affect treatment costs and the use of healthcare services?
Herbild, L., Bech, M., Gyrd-Hansen, D., Christensen, M., Werge, T., & Nielsen, K. A. (2011).
Scandinavian Journal of Public Health, 39(2), 147-55. DOI: 10.1177/1403494810393300

Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and age of onset in schizophrenia: A combined analysis of independent samples.
Saetre, P., Vares, M., Werge, T., Andreassen, O. A., Arinami, T., Ishiguro, H., … Jönsson, E. G. (2011).
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 156(2), 215-24. DOI: 10.1002/ajmg.b.31160

The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1.
Nexø, B. A., Christensen, T., Frederiksen, J., Møller-Larsen, A., Oturai, A. B., Fredsted, P. V., … Pedersen, F. S. (2011).
P L o S One, 6(2), e16652. DOI: 10.1371/journal.pone.0016652

Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associated with disease risk and cortical surface area.
Kähler, A. K., Djurovic, S., Rimol, L. M., Brown, A. A., Athanasiu, L., Jönsson, E. G., … Andreassen, O. A. (2011).
Biological Psychiatry, 69(1), 90-6. DOI: 10.1016/j.biopsych.2010.07.035

Copy number variations of chromosome 16p13.1 region associated with schizophrenia.
Ingason, A., Rujescu, D., Cichon, S., Sigurdsson, E., Sigmundsson, T., Pietiläinen, O. P. H., … GROUP Investigators (2011).
Molecular Psychiatry, 16(1), 17-25. DOI: 10.1038/mp.2009.101

Expanding the range of ZNF804A variants conferring risk of psychosis.
Steinberg, S., Mors, O., Børglum, A., Gustafsson, O., Werge, T., Mortensen, P. B., … Genetic Risk and Outcome in Psychosis (2011).
Molecular Psychiatry, 16(1), 59-66. DOI: 10.1038/mp.2009.149

Altered limbic microstructure in antipsychotic-naïve first-episode schizophrenia patients and associations with the schizophrenia susceptibility gene ZNF804A.
Ebdrup, B., Baare, W., Hansen, T., Rasmussen, H., Aggernaes, B., Werge, T., … Skimminge, A. (2011).
Abstract fra ESMRMB, .

Dual association of a TRKA polymorphism with schizophrenia.
Van Schijndel, J. E., Van Zweeden, M., Van Loo, K. M. J., Djurovic, S., Andreassen, O. A., Hansen, T., … Martens, G. J. M. (2011).
Psychiatric Genetics, 21(3), 125-31. DOI: 10.1097/YPG.0b013e3283437194

Effects of cannabinoid CB(1) receptor agonism and antagonism on SKF81297-induced dyskinesia and haloperidol-induced dystonia in Cebus apella monkeys.
Madsen, M. V., Peacock, L. P., Werge, T., Andersen, M. H., & Andreasen, J. T. (2011).
Neuropharmacology, 60(2-3), 418-22. DOI: 10.1016/j.neuropharm.2010.10.014

GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia.
Chen, X., Lee, G., Maher, B. S., Fanous, A. H., Chen, J., Zhao, Z., … Kendler, K. S. (2011).
Molecular Psychiatry, 16(11), 1117-29. DOI: 10.1038/mp.2010.96

Meta-analysis of heterogeneous data sources for genome-scale identification of risk genes in complex phenotypes.
Pers, T. H., Hansen, N. T., Lage, K., Koefoed, P., Dworzynski, P., Miller, M. L., … Brunak, S. (2011).
Genetic Epidemiology, 35(5), 318-32. DOI: 10.1002/gepi.20580

Novel variant of CYP2D6*6 is undetected by a commonly used genotyping procedure.
Rasmussen, H. B., & Werge, T. (2011).
Pharmacological Reports, 63(5), 1264-6.

The Complement Control-Related Genes CSMD1 and CSMD2 Associate to Schizophrenia.
Håvik, B., Le Hellard, S., Rietschel, M., Lybæk, H., Djurovic, S., Mattheisen, M., … Steen, V. M. (2011).
Biological Psychiatry, 70(1), 35-42. DOI: 10.1016/j.biopsych.2011.01.030

 

2010

Tryptophan hydroxylase gene 1 (TPH1) variants associated with cerebrospinal fluid 5-hydroxyindole acetic acid and homovanillic acid concentrations in healthy volunteers.
Andreou, D., Saetre, P., Werge, T., Andreassen, O. A., Agartz, I., Sedvall, G. C., … Jönsson, E. G. (2010).
Psychiatry Research, 180(2-3), 63-7. DOI: 10.1016/j.psychres.2009.11.018

Association analysis of PALB2 and BRCA2 in bipolar disorder and schizophrenia in a scandinavian case-control sample.
Tesli, M., Athanasiu, L., Mattingsdal, M., Kähler, A. K., Gustafsson, O., Andreassen, B. K., … Andreassen, O. A. (2010).
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 153B(7), 1276-82. DOI: 10.1002/ajmg.b.31098

An exploratory model for G x E interaction on hippocampal volume in schizophrenia; obstetric complications and hypoxia-related genes.
Haukvik, U. K., Saetre, P., McNeil, T., Bjerkan, P. S., Andreassen, O. A., Werge, T., … Agartz, I. (2010).
Progress in neuro-psychopharmacology & biological psychiatry, 34(7), 1259-65. DOI: 10.1016/j.pnpbp.2010.07.001

Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1.
Anttila, V., Stefansson, H., Kallela, M., Todt, U., Terwindt, G. M., Calafato, M. S., … International Headache Genetics Consortium (2010).
Nature Genetics, 42(10), 869-73. DOI: 10.1038/ng.652

No influence of the polymorphisms CYP2C19 and CYP2D6 on the efficacy of cyclophosphamide, thalidomide, and bortezomib in patients with Multiple Myeloma.
Vangsted, A. J., Søeby, K., Klausen, T. W., Abildgaard, N., Andersen, N. F., Gimsing, P., … Rasmussen, H. B. (2010).
B M C Cancer, 10, 404. DOI: 10.1186/1471-2407-10-404

Diastolic dysfunction predicts new-onset atrial fibrillation and cardiovascular events in patients with acute myocardial infarction and depressed left ventricular systolic function: a CARISMA substudy.
Jons, C., Joergensen, R. M., Hassager, C., Gang, U. J. O., Dixen, U., Johannessen, A., … Thomsen, P. E. B. (2010).
European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, 11(7), 602-7. DOI: 10.1093/ejechocard/jeq024

Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples.
Le Hellard, S., Mühleisen, T. W., Djurovic, S., Fernø, J., Ouriaghi, Z., Mattheisen, M., … Steen, V. M. (2010).
Molecular Psychiatry, 15(5), 463-72. DOI: 10.1038/mp.2008.110

A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia.
Ingason, A., Giegling, I., Cichon, S., Hansen, T., Rasmussen, H. B., Nielsen, J., … GROUP Investigators (2010).
Human Molecular Genetics, 19(7), 1379-86. DOI: 10.1093/hmg/ddq009

Det genetiske grundlag for psykiske lidelser.
Werge, T., & Fink-Jensen, A. (2010).
Ugeskrift for laeger, 172(12), 962.

Association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and age of onset in schizophrenia.
Vares, M., Saetre, P., Deng, H., Cai, G., Liu, X., Hansen, T., … Jönsson, E. G. (2010).
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 153B(2), 610-8. DOI: 10.1002/ajmg.b.31030

The tryptophan hydroxylase 1 (TPH1) gene, schizophrenia susceptibility, and suicidal behavior: a multi-centre case-control study and meta-analysis.
Saetre, P., Lundmark, P., Wang, A., Hansen, T., Rasmussen, H. B., Djurovic, S., … Jönsson, E. G. (2010).
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 153B(2), 387-96. DOI: 10.1002/ajmg.b.30991

Genetic susceptibility factors for multiple chemical sensitivity revisited.
Berg, N. D., Rasmussen, H. B., Linneberg, A., Andersen, C. B., Fenger, M., Dirksen, A., … Elberling, J. (2010).
International Journal of Hygiene and Environmental Health, 213(2), 131-9. DOI: 10.1016/j.ijheh.2010.02.001

CACNA1C (rs1006737) is associated with schizophrenia.
Nyegaard, M., Demontis, D., Foldager, L., Hedemand, A., Flint, T. J., Sørensen, K. M., … Børglum, A. D. (2010).
Molecular Psychiatry, 15(2), 119-21. DOI: 10.1038/mp.2009.69

Association study of PDE4B gene variants in Scandinavian schizophrenia and bipolar disorder multicenter case-control samples.
Kähler, A. K., Otnaess, M. K., Wirgenes, K. V., Hansen, T., Jönsson, E. G., Agartz, I., … Djurovic, S. (2010).
American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 153B(1), 86-96. DOI: 10.1002/ajmg.b.30958

Genomic copy number variation in schizophrenia: rare structural variants as an important source of schizophrenia susceptibility: indications of aetiological overlap with other neurodevelopmental disorders.
Ingason, A. (2010).
København: University of Copenhagen.

Neuregulin-1 genotypes and eye movements in schizophrenia.
Haraldsson, H. M., Ettinger, U., Magnusdottir, B. B., Ingason, A., Hutton, S. B., Sigmundsson, T., … Petursson, H. (2010).
European Archives of Psychiatry and Clinical Neuroscience, 260(1), 77-85. DOI: 10.1007/s00406-009-0032-2

 

2009

Expression analyses of human cleft palate tissue suggest a role for osteopontin and immune related factors in palatal development.
Jakobsen, L. P., Borup, R., Vestergaard, J., Larsen, L. A., Lage, K., Maroun, L. L., … Tommerup, N. (2009).
Experimental Biology and Medicine, 41(2), 77-85. DOI: 10.3858/emm.2009.41.2.010

 

2008

Association between a disrupted-in-schizophrenia 1 (DISC1) single nucleotide polymorphism and schizophrenia in a combined Scandinavian case-control sample.
Saetre, P., Agartz, I., De Franciscis, A., Lundmark, P., Djurovic, S., Kähler, A., … Jönsson, E. G. (2008).
Schizophrenia research, 106(2-3), 237-41. DOI: 10.1016/j.schres.2008.08.024

Correlation between genetic and geographic structure in Europe.
Lao, O., Lu, T. T., Nothnagel, M., Junge, O., Freitag-Wolf, S., Caliebe, A., … Kayser, M. (2008).
Current Opinion in Cell Biology, 18(16), 1241-8. DOI: 10.1016/j.cub.2008.07.049

Advice on the genotyping of CYP2C19: comments on a recent article.
Rasmussen, H. B., & Werge, T. (2008).
Pharmacogenetics and Genomics, 18(7), 647-8; author reply 648-9. DOI: 10.1097/FPC.0b013e328300e8b2

Misclassification of allele CYP2C19*10 as CY2C19*2 by a commonly used PCR-RFLP procedure.
Rasmussen, H., & Werge, T. (2008).
Genetic Testing and Molecular Biomarkers, 12(1), 57-8. DOI: 10.1089/gte.2007.0055

 

2007

Impaired glutathione synthesis in schizophrenia: convergent genetic and functional evidence.
Gysin, R., Kraftsik, R., Sandell, J., Bovet, P., Chappuis, C., Conus, P., … Do, K. Q. (2007).
Proceedings of the National Academy of Sciences of the United States of America, 104(42), 16621-6. DOI: 10.1073/pnas.0706778104

Novel procedure for genotyping of the human serotonin transporter gene-linked polymorphic region (5-HTTLPR)–a region with a high level of allele diversity.
Rasmussen, H. B., & Werge, T. M. (2007).
Psychiatric Genetics, 17(5), 287-91. DOI: 10.1097/YPG.0b013e328133f331

The acetylcholinesterase inhibitor galantamine inhibits d-amphetamine-induced psychotic-like behavior in Cebus monkeys.
Andersen, M. B., Werge, T., & Fink-Jensen, A. (2007).
The Journal of pharmacology and experimental therapeutics, 321(3), 1179-82. DOI: 10.1124/jpet.107.119677

The tachykinin tale: molecular recognition in a historical perspective.
Werge, T. (2007).
Journal of molecular recognition : JMR, 20(3), 145-53. DOI: 10.1002/jmr.822

 

2006

Effects of the cannabinoid CB1 receptor agonist CP55,940 and antagonist SR141716A on d-amphetamine-induced behaviours in Cebus monkeys.
Madsen, M. V., Peacock, L., Werge, T., & Andersen, M. B. (2006).
Journal of psychopharmacology (Oxford, England), 20(5), 622-8. DOI: 10.1177/0269881106063816

Cognitive impairment in elderly women: the relative importance of selected genes, lifestyle factors, and comorbidities.
Rasmussen, H. B., Bagger, Y. Z., Tankó, L. B., Qin, G., Christiansen, C., & Werge, T. (2006).
Neuropsychiatric Disease and Treatment, 2(2), 227-33.

No association between the -399 C > T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population.
Lindberg, C., Koefoed, P., Hansen, E. S., Bolwig, T. G., Rehfeld, J. F., Mellerup, E., … Woldbye, D. P. D. (2006).
Acta Psychiatrica Scandinavica, 113(1), 54-8. DOI: 10.1111/j.1600-0447.2005.00648.x

 

2005

Psykofarmakologi i et genomisk perspektiv.
Werge, T., & Kessing, L. V. (2005).
Ugeskrift for laeger, 167(20), 2194-6.