PGC – PSYCHIATRIC GENOMICS CONSORTIUM.
The purpose of the Psychiatric Genomics Consortium (PGC) is to unite investigators around the world to conduct meta- and mega-analyses of genome-wide genomic data for psychiatric disorders. The PGC includes over 800 investigators from 38 countries, and it is the largest consortium and the largest biological experiment in the history of psychiatry.
Headquartered in Reykjavik, Iceland, deCODE is a global leader in analyzing and understanding the human genome. Using unique expertise and population resources, deCODE has discovered key genetic risk factors for dozens of common diseases ranging from cardiovascular disease to cancer, and they operate one the most productive human gene discovery engines in the world.
NORMENT – NORWEGIAN CENTRE FOR MENTAL DISORDERS RESEARCH.
Norment has a clear clinical profile, involving investigations of participants with state-of-the-art clinical assessments and research technology, as well as translating findings to experimental studies for the identification of disease mechanisms and development of new treatment.
Lundbeck is a global pharmaceutical company that is deeply committed to improving the quality of life for people suffering from brain disease
The iPSYCH INITIATIVE.
The iPSYCH Initiative was established in 2012 through a donation by the Lundbeck Foundation of 121 million DKK for an initial three year period – the largest grant ever to Danish psychiatric research. Since then, it has been extended twice with identical grants, most recently in March 2018. The iPSYCH initiative studies five mental disorders: autism, ADHD, schizophrenia, bipolar disorder and depression. It capitalizes on the comprehensive Danish civil and health registers and nationwide biobanks to provide population structure, clinical information and biomaterial for multi-OMICs analysis. Currently, the initiative have generated SNP-array on 80,000 DNA samples and whole exome sequencing data on 7,000 DNA samples to be combined with extensive register-data on environmental exposures and phenotypic data from hospital registers. Ongoing work is aiming to perform metabolomics and possibly transcriptomics on the same neonatal blood spots. In parallel clinical and translational studies are being conduction on patients and transgenic animals. iPSYCH partners include Institute of Biological Psychiatry, Mental Health Centre Copenhagen, Capital Region of Denmark, Department of Biomedicine, Aarhus University, Denmark, National Centre for Register-based Research, Aarhus University, Denmark, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Risskov. In 2012, iPSYCH received the largest grant ever given to the psychiatric research in Denmark from the Lundbeck Foundation of EUR 49 million over the course of nine years.
SSI – STATENS SERUM INSTITUT.
SSI is one of Denmark’s largest healthcare research institutes. They house several internationally leading research groups, and their research focus is diagnostics related to prevention and treatment, epidemiological surveillance and research, as well as vaccine research.
STANLEY CENTER FOR PSYCHIATRIC RESEARCH AT BROAD.
Based on BROAD Institute at MIT and Havard, The Stanley Center aims to exploit the most advanced technologies for human genetic analysis to study psychiatric disorders in order to understand disease mechanisms, identify potential biomarkers, and ignite needed progress in therapeutics.
Situated at Massachusetts General Hospital, Harvard Medical School, and the Broad Institute of MIT and Harvard, The Lage Lab develop and apply computational technologies to functionally interpret massive genomic datasets using biological networks. They aim to understand and model how biological networks are perturbed by genetics and can be targeted by therapeutics in complex diseases such as psychiatric disorders, cancers, and metabolic diseases. And they make all tools available to the scientific community and collaborate widely with disease experts at the genetic, experimental and clinical level.
DBDS – THE DANISH BLOOD DONOR STUDY.
The Danish Blood Donor Study is a project that will benefit both blood donors and Danish patients in the control of diseases. Blood donors’ blood is being investigated for biological markers that can explain or predict disease. The research is based on voluntary participation of Danish blood donors.
Following several hundred children, VIA7/11 investigates the vulnerability and resilience of children with a family risk of mental disorders, because of their parents either have or has had a psychosis or bipolar disorder. The study is voluntary, and the children are studied with comprehensive psychopathological assessments, neuropsychological tests, MRI, and EEG.
CENTRE FOR GEOGENETICS.
Using whole-genome sequencing to extract the maximum information from study samples, Center for Geogenetics focuses on ancient DNA, environmental DNA and human evolution to disease association and animal domestication. Led by Eske Willerslev, Center for Geogenetics is a world leader in ancient DNA research with numerous publications in Nature, Science and other high-ranking journals.
Therapeutic research is carried out into medicines and different forms of psychotherapy. Research is also conducted on drug use and dependency. Psychiatric conditions are also placed in a social context. Issues related to the care and management of mentally disordered offenders are often complicated and involve knowledge from several different areas of medicine, law, as well as psychology. As a result, the forensic psychiatric research field refers to varied aspects of the interplay between law, medicine and the behavioural sciences.